Whether you are fan of the CGI::Application module or would like to know more about it, two new new Wikis have been created based around it. One is based on the Twiki software and the other is based on Kwiki.
CGI::Application is really more of a development framework and philosophy, as I imagine Template::Toolkit is.
I really like CGI::Application and use it for nearly all my web projects. I find it provides useful functions without imposing too much structure on me. It also has a very strong benefit of helping to create highly re-usable code, by maximizing the amount that is in modules. In this structure, it's easy to re-use an application with a completely different template set providing a new look and feel, but using the same core Perl modules.