I was playing with apache 2.0 again last night, and I'm mightily impressed with it.
Perusing the docs, it looks like it might be possible to do a thick/thin apache/mod_perl set up using virtual hosts bound to different ports, rather than the two instances of apache which I've seen documented for 1.3, which would be pretty cool*. Looks like I have something to look into this weekend.
* in the geek sense.