A trickle of people have started to use Pod::Simple::Wiki.
Sam Tregar sent a patch for TWiki and Tony Sidaway sent one for Wikipedia (example).
One of the strange(r) things about parsing Pod (even with the help of Pod::Simple) is the bizarre little ecosystem that can exist in =over, =back regions. See the relevant section of perlpodspec for the gory details. The plain part of that part of Pod could be plainer.
Maybe Perl6 or Kwid will fix this.