I am happy to let you know that Padre is now available as a ppm distribution for Active Perl 5.10 on Windows.
In order to install it you'll need to add two repositories:
ppm rep add wxperl http://www.wxperl.co.uk/repository ppm rep add padre http://www.perlide.org/download/ppm/and then you can install:
ppm install Alien-wxWidgest ppm install Wx ppm install PadreFor up to date information see the Download page of Padre