So, you want to use DBD::mysql on Panther (Mac OS X 10.3) using the default Perl? Won't build, huh?
After you build the Makefile, do this.
perl -pi -e's/MACOSX/env MACOSX/' Makefile
When 5.8.2 comes along, that won't be necessary. If you're going to build your own 5.8.1, update your hints before you build.
perl -pi -e's/ld="MACOSX/ld="env MACOSX/' hints/darwin.sh
Happy Panther day.