Devel::NYTProf 2.04 is out. Tim has blogged about the "big"* improvement - it now takes about 10 times as long to fill your disk. Yes, profiles are now compressed as they are written. For significant sized programs this is a big win:
NYTProf 2.03 was producing profile data at the rate of about 13MB per million statements executed. That might not sound too bad until you realise that on modern systems with cpu intensive code, perl can execute millions of statements every few seconds.
* or small